Is it worth taking a chance with this drug considering the possible side effects?

If it works it works. But these side effects are off the charts.

Otezla (apremilast) is a phosphodiesterase 4 (PDE4) inhibitor used to treat adult patients with active psoriatic arthritis. Common side effects of Otezla include:

diarrhea,
headache,
nausea,
upper respiratory tract infection,
vomiting,
runny or stuffy nose,
abdominal pain,
fatigue,
indigestion/heartburn,
decreased appetite,
insomnia,
back pain,
frequent bowel movements,
depression,
bronchitis,
tooth abscess, and
sinus headache.
Other side effects of Otezla include hypersensitivity, weight loss, gastroesophageal reflux disease (GERD), migraine, cough, and rash.

The recommended maintenance dosage is 30 mg twice daily taken orally starting on Day 6, after 5 days of an initial schedule of titration dosing. Otezla may interact with CYP450 inducers (such as rifampin). Tell your doctor all medications and supplements you use. During pregnancy, Otezla should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.