SpaceX Crew-1 (also known as USCV-1 or simply Crew-1) is the first operational crewed flight of a Crew Dragon spacecraft. It is also the first crewed night launch by the United States since that of STS-130 in February 2010. The Crew Dragon spacecraft Resilience launched on 16 November 2020 at 00:27:17 UTC on a Falcon 9 from the Kennedy Space Center, LC-39A, carrying NASA astronauts Michael Hopkins, Victor Glover and Shannon Walker along with JAXA astronaut Soichi Noguchi, all members of the Expedition 64 crew. The mission is the second overall crewed orbital flight of the Crew Dragon.

Crew-1 is the first operational mission to the International Space Station in the Commercial Crew Program. Originally designated “USCV-1” by NASA in 2012, the launch date was delayed several times from the original date of November 2016. The mission is expected to last 180 days, meaning the flight will return to Earth sometime around May 2021. Resilience is expected to return to Earth via splashdown for reuse for another future mission.