C.I.S.O. (Canadian International Security Organization), from the Captain Canuck comic book series. Not to be confused with C.S.I.S., the current Canadian spy agency.
C.L.I.T.O.R.I.S. (The Committee for the Liberation and Integration of Terrifying Organisms and their Rehabilitation Into Society), from Red Dwarf
C.O.B.R.A. (Criminal Organization of Bloodiness, Revenge and Assassination), an international terrorist organization, headed by Cobra Commander, from the G.I. Joe series.
G.R.A.M.P.A. (Global Reaction Agency for Mysterious Paranormal Activity), an international intelligence agency in Marvel Comics.
I.S.I.S (International Secret Intelligence Service) is the agency employing the lead characters in Archer (TV series). Not to be confused with those blood thirsty Muslim terrorists.
K.A.B.O.O.M. (Key Atomic Benefits Organization of Mankind), from the movie The Naked Gun 2½: The Smell of Fear.
SPECTRE (Special Executive for Counter-intelligence, Terrorism, Revenge, and Extortion), from the James Bond series.
- T.H.U.N.D.E.R.(The Higher United Nations Defense Enforcement Reserves), from Tower Comics.
U.G.L.I. (Undercover Global League of Informants) in the Hardy Boys book, Secret Agent of Flight 101.
U.N.C.L.E. (United Network Command for Law and Enforcement) and T.H.R.U.S.H., from The Man from U.N.C.L.E.. (The meaning of T.H.R.U.S.H. was never revealed on the series; but, in the novelizations it was stated to be “Technological Hierarchy for the Removal of Undesirables and the Subjugation of Humanity”.)
V.E.N.O.M. (The Vicious, Evil Network Of Mayhem), the evil mask-wearing cohort from the 1980s Saturday-morning cartoon M.A.S.K.
V.I.L.E. (The Villains’ International League of Evil), Carmen Sandiego’s band of international thieves.
Z.O.W.I.E. (Zonal Organization for World Intelligence and Espionage), from the movies Our Man Flint and In Like Flint.