Is it worth taking a chance with this drug considering the possible side effects?

If it works it works. But these side effects are off the charts.

Otezla (apremilast) is a phosphodiesterase 4 (PDE4) inhibitor used to treat adult patients with active psoriatic arthritis. Common side effects of Otezla include:

diarrhea,
headache,
nausea,
upper respiratory tract infection,
vomiting,
runny or stuffy nose,
abdominal pain,
fatigue,
indigestion/heartburn,
decreased appetite,
insomnia,
back pain,
frequent bowel movements,
depression,
bronchitis,
tooth abscess, and
sinus headache.
Other side effects of Otezla include hypersensitivity, weight loss, gastroesophageal reflux disease (GERD), migraine, cough, and rash.

The recommended maintenance dosage is 30 mg twice daily taken orally starting on Day 6, after 5 days of an initial schedule of titration dosing. Otezla may interact with CYP450 inducers (such as rifampin). Tell your doctor all medications and supplements you use. During pregnancy, Otezla should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Bill O’Reilly points finger at “God” after accusations of sexual harassment

Bill O’Reilly has seemingly run out of options for blaming others after a series of sexual harassment allegations canned the former Fox News host. From accusers to the news media, the only logical scapegoat left would surely be his Almighty.

During a recent episode of his web series “No Spin News,” O’Reilly spoke candidly about his anger toward God for not protecting him, as more details surrounding allegations have surfaced, according to CNN.

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“You know, am I mad at God? Yeah, I’m mad at him,” O’Reilly said. “I wish I had more protection. I wish this stuff didn’t happen. I can’t explain it to you. Yeah, I’m mad at him.”

He also admitted people have it “much rougher” than him and that he’s a “bigmouth.”

The New York Times reported Saturday that O’Reilly paid $32 million to settle accusations with former Fox News contributor Lis Wiehl. Six other agreements have been made by either O’reilly or the network on his behalf.

With this latest rant under his belt, his New York Times bestseller Killing Jesus: A History is beginning to look more like a manifesto.

Rock Stars and Musicians that died at age 27, very bizarre

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The number of rockers who were taken from us too early in life — whether by accident, violence or misadventure — is obviously far too large. The fact that so many of the biggest and most influential talents in rock history died at the age of 27 is even more bizarre, and when you think about it, downright creepy.

Over the years, the stories behind the deaths of the members of this so called “27 club” have grown more and more inflated and outrageous, with everything from legal cover-ups to elaborate hoaxes and even deals with the devil trotted out to try and make some sense of these tragic losses.

Together with our friends at Loudwire, we try to distinguish fact from fiction regarding these sad stories on the following list of Rockers Who Died at Age 27.

 Brian Jones, Jimi Hendrix, Janis Joplin and Jim Morrison all died at the age of 27 between 1969 and 1971. At the time, the coincidence gave rise to some comment but it was not until the death of Kurt Cobain, about two and a half decades later, that the idea of a “27 Club” began to catch on in public perception.

According to Hendrix and Cobain biographer Charles R. Cross, the growing importance of the media—Internet, television and magazines—and the response to an interview of Cobain’s mother were jointly responsible for such theories. An excerpt from a statement that Cobain’s mother, Wendy Fradenburg Cobain O’Connor, made in the Aberdeen, Washington newspaper The Daily World—”Now he’s gone and joined that stupid club. I told him not to join that stupid club.”—referred to Hendrix, Joplin, and Morrison dying at the same age, according to Cross. Other authors share his view. On the other hand, Josh Hunter and Eric Segalstad, writer of The 27s: The Greatest Myth of Rock & Roll, assumed that Cobain’s mother referred to the death of his two uncles and his great uncle, who all committed suicide. According to Cross, the events have led a “set of conspiracy theorists [to suggest] the absurd notion that Kurt Cobain intentionally timed his death so he could join the 27 Club”.

In 2011, seventeen years after Cobain’s death, Amy Winehouse died at the age of 27, and there was a large amount of media attention devoted to the club once again. Three years earlier, she had expressed a fear of dying at that age.

People identified as being in the 27 Club

Name Date of death Official cause of death Fame Age
Levy, Alexandre January 17, 1892 Unknown Composer, pianist and conductor 27 years, days  
Chauvin, Louis March 26, 1908 Neurosyphilitic sclerosis Ragtime musician 27 years, 13 days  
Johnson, Robert August 16, 1938 Poisoning (Strychnine) Blues singer and musician who recorded a very influential set of 29 songs. 27 years, 100 days  
Nat Jaffe August 5, 1945 Complications from high blood pressure Swing jazz pianist 27 years, 216 days  
Jesse Belvin February 6, 1960 Traffic collision (car) R&B singer, pianist and songwriter 27 years, 53 days  
Lewis, Rudy 01964-05-20-0000May 20, 1964 Drug overdose Vocalist of the Drifters 27 years, 271 days  
Henderson, Joe October 24, 1964 Heart attack R&B and gospel singer 27 years, 183 days  
Hale, Malcolm ! 01968-10-31-0000October 31, 1968 Poisoning (carbon monoxide) Original member and lead guitarist of Spanky and Our Gang 27 years, 166 days  
Pride, Dickie March 26, 1969 Drug overdose (sleeping pills) Rock and roll singer 27 years, 156 days  
Jones, Brian 01969-07-03-0000July 3, 1969 Drowning(coroner’s report states “death by misadventure”) Rolling Stones founder, guitarist and multi-instrumentalist 27 years, 125 days  
Wilson, Alan “Blind Owl” 01970-09-03-0000September 3, 1970 Drug overdose (barbiturate), possible suicide Leader, singer and primary composer of Canned Heat 27 years, 61 days  
Hendrix, Jimi September 18, 1970 Asphyxiation Pioneering electric guitarist, singer and songwriter for the Jimi Hendrix Experience and Band of Gypsys 27 years, 295 days  
Joplin, Janis October 4, 1970 Drug overdose (probable, heroin) Lead vocalist and songwriter for Big Brother and the Holding Company, the Kozmic Blues Band and Full Tilt Boogie Band 27 years, 258 days  
Arlester “Dyke” Christian March 13, 1971 Murdered Frontman, vocalist and bassist of Dyke and the Blazers 27 years, 273 days  
Morrison, Jim 01971-07-03-0000July 3, 1971 Heart failure Singer, lyricist, and leader of the Doors 27 years, 207 days  
Jones, Linda March 14, 1972 Complications from diabetes Soul singer 27 years, 91 days  
Harvey, Leslie May 3, 1972 Electrocution Guitarist for Stone the Crows and brother of Alex Harvey 27 years, 233 days  
Ron “Pigpen” McKernan March 8, 1973 Gastrointestinal hemorrhage Founding member, keyboardist and singer of the Grateful Dead 27 years, 181 days  
Roger Lee Durham July 27, 1973 Fell off a horse and died from the injuries Singer and percussionist of Bloodstone 27 years, 163 days  
Yohn, Wallace !Wallace Yohn 01974-08-12-0000August 12, 1974 Plane crash Organ player of Chase 27 years, 212 days  
Alexander, Dave February 10, 1975 Pulmonary edema Bassist for the Stooges 27 years, 252 days  
Ham, Pete April 24, 1975 Suicide by hanging Keyboardist and guitarist, leader of Badfinger 27 years, 362 days  
Thain, Gary December 8, 1975 Drug overdose (heroin) Former bassist of Uriah Heep and the Keef Hartley Band 27 years, 207 days  
Cecilia August 2, 1976 Traffic collision (car) Singer 27 years, 296 days  
Köllen, Helmut May 3, 1977 Poisoning (carbon monoxide) Bassist for 1970s prog rock band Triumvirat 27 years, 27 days  
Bell, Chris December 27, 1978 Traffic collision (car) Singer-songwriter and guitarist of power pop band Big Star and solo 27 years, 349 days  
Miller, Jacob March 23, 1980 Traffic collision (car) Reggae artist and lead singer for Inner Circle 27 years, 324 days  
Boon, D. December 22, 1985 Traffic collision (van) Guitarist, lead singer of punk band the Minutemen 27 years 266 days  
Bashlachev, Alexander February 17, 1988 Fall from a height, probable suicide Poet, rock musician and songwriter 27 years 266 days  
Basquiat, Jean-Michel August 12, 1988 Drug overdose (Speedball) Painter and graffiti artist; formed the band Gray 27 years, 234 days  
de Freitas, Pete June 14, 1989 Traffic collision (motorcycle) Drummer for Echo & the Bunnymen 27 years, 346 days  
Zapata, Mia July 7, 1993 Murdered Lead singer of the Gits 27 years, 316 days  
Cobain, Kurt April 5, 1994 c. Suicide by gunshot Founding member, lead singer, guitarist and songwriter for Nirvana 27 years, 44 days  
Pfaff, Kristen June 16, 1994 Drug overdose (heroin) Bass guitarist for Hole and Janitor Joe 27 years, 21 days  
Edwards, Richey February 1, 1995 Disappeared; officially presumed dead November 23, 2008 Lyricist and guitarist for Manic Street Preachers 27 years, 41 days  
Pat, Fat February 3, 1998 Murdered American rapper and member of Screwed Up Click 27 years, 61 days  
Tah, Freaky 01999-03-28-0000March 28, 1999 Murdered American rapper and member of the hip hop group Lost Boyz 27 years, 318 days  
Kami June 21, 1999 Subarachnoid hemorrhage Drummer for Malice Mizer 27 years, 140 days  
Bueno, Rodrigo June 24, 2000 Traffic collision (car) Cuarteto singer 27 years, 31 days  
Sean Patrick McCabe August 28, 2000 Asphyxiation Lead singer of Ink & Dagger 27 years, 289 days  
Maria Serrano Serrano November 24, 2001 Plane crash (Crossair Flight 3597) Background singer for Passion Fruit 27 years, 363 days  
Ward, Jeremy Michael May 25, 2003 Drug overdose (heroin) The Mars Volta and De Facto sound manipulator 27 years, 20 days  
Ottoson, Bryan !Bryan Ottoson 02005-04-19-0000April 19, 2005 Drug overdose (prescription medication) Guitarist for American Head Charge 27 years, 32 days  
Elizalde, Valentín November 26, 2006 Murdered Mexican banda singer 27 years, 297 days  
Winehouse, Amy 02011-07-23-0000July 23, 2011 Poisoning (alcohol) Singer-songwriter 27 years, 312 days  
Richard Turner August 11, 2011 Cardiac arrest Trumpet player, collaborator with Friendly Fires 27 years, 12 days  
Nicole Bogner January 6, 2012 Undisclosed illness Singer for Visions of Atlantis 27 years 290 days  
Soroush “Looloosh” Farazmand November 11, 2013 Murdered Guitarist for the Yellow Dogs 27 years, 11 days  
Monkey Black April 30, 2014 Murdered Dominican rapper and singer 27 years  278 days  
Slađa Guduraš ! December 10, 2014 Road accident Bosnian pop singer and actress 27 years, 121 day

Airstream Travel Trailer Goes Airborne

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Back in the early 1990’s the United States Air Force (USAF) was tasked with a mission to develop an airborne mobile command center which could provide a long-range transportation and global communications capability for use by travelling VIP’s. This Distinguished Visitor (DV) program required that the USAF create a command and control module (CCM) that can quickly and easily be loaded on to a variety of different military transport aircraft – like the C-141, C-17, KC-10, KC-135 & C-130 – and be rapidly dispatched to any theatre of operations. Although a number of bespoke solutions were offered at the time, the provisional (and by far the cheapest) option was a palletized 36-foot Airstream travel trailer with an embedded communications suite. This asset package – designated as the “C2” in military parlance – came to be known as the “Silver Bullet.”

C-17 Globemaster III

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An Airstream being loaded into a C-17

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The help sit in the cargo cabin

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Former Secretary of Defense Robert Gates in the airborne Airstream

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Inside Google’s Giant Data Centers

Inside the internet: Google allows first ever look at the eight vast data centres that power the online world

  • Data centres range from vast warehouses in Iowa to a converted paper mill in Finland
  • Buildings are so large Google even provides bicycles for engineers to get around them
  • Street View tour of North Carolina facility reveals Stormtrooper standing guard

Google has given a rare glimpse inside the vast data centres around the globe that power its services.

They reveal an intricate  maze of computers that process Internet search requests, show  YouTube video clips and distribute email for millions of people.

With hundreds of thousands of servers, colourful cables and even bicycles so engineers can get around quickly, they  range from a converted paper mill in Finland to custom made server farms in Iowa.

 

One of Google’s server farms in Council Bluffs, Iowa, which provides over 115,000 square feet of space for servers running services like Search and YouTube

‘Very few people have stepped inside Google’s  data centers, and for good reason: our first priority is the privacy and security of your data, and we go to great lengths to protect it, keeping our  sites under close guard,’ the firm said.

‘While we’ve shared many of our designs and best practices, and we’ve been publishing our efficiency data since 2008, only a small set of employees have access to the server floor itself.

‘Today, for the first time, you can see inside our data centers and pay them a virtual visit.

‘On Where the Internet lives, our new site featuring beautiful photographs by Connie Zhou, you’ll get a never-before-seen  look at the technology, the people and the places that keep Google running.’

The site features photos from inside some of the eight data centers that Google Inc. already has running in the U.S., Finland  and Belgium.

Google is also building data centers in Hong Kong, Taiwan, Singapore and Chile.

Virtual tours of a North Carolina data center also will be available through Google’s ‘Street View’ service, which is usually used to view photos of neighborhoods around the world.

The photographic access to Google’s data centers coincides with the publication of a Wired magazine article about how the  company builds and operates them.

The article is written by Steven Levy, a journalist who won Google’s trust while writing ‘In The Plex,’ a book published last year about the company’s philosophy and evolution.

Google colour codes its servers depending on their location, while piping in the  buildings is coded depending on what it carries – with cool water in blue tubes and warm in red

 

Google’s Douglas County data centre in Georgia is so large the firm provides Google branded bicycles for staff to get around on

The data centers represent Google’s  nerve  center, although none are located near the company’s headquarters  in Mountain View, Calif.

As Google blossomed from its roots in a Silicon Valley garage, company co-founders Larry Page and Sergey Brin worked  with other engineers to develop a system to connect low-cost computer servers  in a way that would help them realize their ambition to provide a digital roadmap to all of the world’s information.

Initially, Google just wanted enough  computing power to index all the websites on the Internet and deliver quick  responses to search requests. As Google’s tentacles extended into  other  markets, the company had to keep adding more computers to store videos, photos,  email and information about their users’ preferences.

 

A street view tour published by Google also reveals a hidden surprise – A Stormtrooper standing guard over a server in Google’s North Carolina server farm

The insights that Google gathers about the  more than 1 billion people that use its services has made the  company a frequent target of privacy complaints around the world.

The latest missive came Tuesday in  Europe, where regulators told Google to revise a 7-month-old change to  its privacy policy that enables the company to combine user data  collected from its different services.

Google studies Internet search requests and Web surfing habits in an effort to gain a better  understanding of what people like. The company does this in an effort to show ads of products and services to the people most likely to be  interested in buying them. Advertising accounts for virtually all of Google’s revenue, which totaled nearly $23 billion through the first  half of this year.

Even as it allows anyone with a Web browser  to peer into its data centers, Google intends to closely guard  physical access to its buildings. The company also remains cagey about how many computers are in its data centers, saying only that they house  hundreds of thousands of machines to run Google’s services.

Google’s need for so many computers has turned the company a major electricity user, although management says it’s constantly looking for ways to reduce power consumption to  protect the  environment and lower its expenses.

 

Here hundreds of fans funnel hot air from the server racks into a cooling unit to be recirculated in Oklahoma. The green lights are the server status LEDs reflecting from the front of the servers

 

The Iowa campus network room, where routers and switches allow data centers to talk to each other. The fiber cables run along the yellow cable trays near the ceiling.

 

Even the water pipes reflect Google’s brand: These colorful pipes are responsible for carrying water in and out of an Oregon data center. The blue pipes supply cold water and the red pipes return the warm water back to be cooled.

 

Google’s server farm in Douglas County, Iowa

 

Denise Harwood, a Google Engineer, diagnoses an overheated CPU. For more than a  decade, Google has built some of the world’s most efficient servers.

 

Each server rack has four switches, connected by a different colored cable.  Colors are kept the same throughout data centers so staff know which one to  replace in case of failure.

Google Street View Protects Cows Privacy by Blurring its Face

At least Google’s face-blurring technology takes privacy seriously — even for non-humans.

The photo was captured in Cambridge, England and shows a cow grazing by a river with a blurred-out face — something Google usually only does for the humans it captures as it drives about photographing cities for its Street View service.

In a statement to the BBC, Google said, “we thought you were pulling the udder one when we herd the moos, but it’s clear that our automatic face-blurring technology has been a little overzealous. Of course, we don’t begrudge this cow milking its five minutes of fame.”

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Here is the real intention. West End Winnipeggers partying on the street.

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Cartoons of the Day

Thousands of Previously Unseen JFK Assassination Files to Be Released This Week

Experts expect the documents will reveal new info on a trip Lee Harvey Oswald took to Mexico, where he met with Cuban and Russian spies.

While the news might excite people who believe that the assassination was an elaborate government conspiracy, experts on the November 1963 assassination say we probably won’t get any explosive new information that would rewrite the history books. According to Philip Shenon and Larry J. Sabato—two historians who have researched the assassination extensively—the documents could shed light on a trip Lee Harvey Oswald took to Mexico weeks before killing JFK, where he met with Cuban and Russian spies. In a piece for Politico, Shenon and Sabato said that “many” of the previously unseen files center on the trip, during which Oswald “came under intense surveillance” by the FBI and purportedly “spoke openly” about wanting to kill JFK.

 

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